Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications.

Morand Piert, Ka Kit Wong

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013;54(4):590-9

PMID: 23482667

Free Full Text on HighWire View on PubMed

Abstract

Dynamic bone scanning with (99m)Tc-labeled diphosphonates and (18)F-labeled sodium fluoride provides functional information sensitive for subtle changes in bone turnover and perfusion, which assists the clinical management of numerous osseous pathologies. This article reviews the mechanisms of uptake of (99m)Tc-labeled diphosphonates and (18)F-sodium fluoride and discusses and compares the performance of these bone-seeking radiotracers for clinical and research applications, using dynamic and multiple-time-point imaging protocols and quantitative techniques.

Address: Nuclear Medicine/Radiology Department, University of Michigan Hospital, Ann Arbor, MI48109-0028, USA.

DOI: 10.2967/jnumed.112.114298

Link outs

Free resources

Full Text Sources:

http://jnm.snmjournals.org/cgi/pmidlookup?view=lon...

Medical:

https://medlineplus.gov/ctscans.html

Other Literature Sources:

https://scite.ai/reports/23482667

MeSH Terms: Biological Transport, Bone and Bones, Fluorine Radioisotopes, Humans, Multimodal Imaging, Positron-Emission Tomography, Sodium Fluoride, Technetium Tc 99m Medronate, Tomography, X-Ray Computed