Clinical MRI for iron detection in Parkinson's disease.

Maija Rossi, Hanna Ruottinen, Seppo Soimakallio, Irina Elovaara, Prasun Dastidar

Journal: Clinical imaging 2014;37(4):631-6

PMID: 23522789

Full Text on Elsevier Science View on PubMed

Abstract

We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2-weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.

Address: Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland. [email protected]

DOI: 10.1016/j.clinimag.2013.02.001

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MeSH Terms: Adult, Aged, Aged, 80 and over, Brain Mapping, Caudate Nucleus, Corpus Callosum, Disease Progression, Female, Globus Pallidus, Humans, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Substantia Nigra