Gastric cancer: epidemiology and risk factors.

Catherine de Martel, David Forman, Martyn Plummer

Journal: Gastroenterology clinics of North America 2014;42(2):219-40

PMID: 23639638

Full Text on Elsevier Science View on PubMed

Abstract

Gastric cancer is one of the major malignancies in the world. This article summarizes the current understanding of the worldwide burden of this disease, its geographic variation, and temporal trends. An overview is presented of known risk factors, including genetic, dietary, and behavioral, but focuses on Helicobacter pylori infection as the most important factor in noncardia gastric cancer. When the data and the literature allow, we distinguish between cardia and noncardia sub-sites, as it is now clear that these two anatomic locations present distinct and sometimes opposite epidemiological characteristics.

Address: International Agency for Research on Cancer, Lyon, France.

DOI: 10.1016/j.gtc.2013.01.003

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MeSH Terms: Alcohol Drinking, Carcinoma, Cardia, Diet, Helicobacter Infections, Helicobacter pylori, Humans, Incidence, Obesity, Risk Factors, Smoking, Social Class, Stomach Neoplasms