Diabetes: Looking back at Look AHEAD--giving lifestyle a chance.

Paul Poirier, Jean-Pierre Després

Journal: Nature reviews. Cardiology 2013;10(4):184-6

PMID: 23419903

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Abstract

The Look AHEAD trial did not show that a lifestyle modification programme aimed at weight loss could reduce the incidence of cardiovascular disease events. We attempt to address why this trial was 'negative', and emphasize that further randomized trials of lifestyle modification focusing on the effects of physical activity and exercise are needed.

DOI: 10.1038/nrcardio.2013.16

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MeSH Terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diet, Early Termination of Clinical Trials, Exercise, Humans, Randomized Controlled Trials as Topic, Risk Factors, Risk Reduction Behavior, Treatment Outcome, Weight Loss