Cycling lipids.

H Stenmark

Journal: Current biology : CB 2000;10(2):R57-9

PMID: 10662657

Free Full Text on Elsevier Science View on PubMed

Abstract

When synaptic vesicles fuse with the presynaptic plasma membrane, their membrane constituents are recycled by internalisation into clathrin-coated vesicles. To form new synaptic vesicles, the clathrin coat must be shed and recent studies reveal that a lipid phosphatase, synaptojanin, plays a central role in this process.

Address: Department of Biochemistry, The Norwegian Radium Hospital, Oslo, N-0310, Norway. [email protected].

DOI: 10.1016/s0960-9822(00)00279-7

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MeSH Terms: Calcium-Binding Proteins, Clathrin, Exocytosis, Membrane Fusion, Membrane Glycoproteins, Membrane Lipids, Nerve Tissue Proteins, Synaptotagmins