RING for destruction?

P S Freemont

Journal: Current biology : CB 2000;10(2):R84-7

PMID: 10662664

Free Full Text on Elsevier Science View on PubMed

Abstract

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.

Address: Molecular Structure and Function Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK. [email protected].

DOI: 10.1016/s0960-9822(00)00287-6

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MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Proteins, Ubiquitins