Managing atrophic nonunion in the geriatric population: incidence, distribution, and causes.

Bryon Hobby, Mark A Lee

Journal: The Orthopedic clinics of North America 2013;44(2):251-6

PMID: 23544828

Full Text on Elsevier Science View on PubMed

Abstract

Osteoporosis is a systemic disease that affects millions of people worldwide. It is estimated that 50% of women and approximately 20% of men more than 50 years of age will sustain a fragility fracture. The cause of nonunion in patients with osteoporosis is likely multifactorial, and includes age-related changes in fracture repair as well as challenges in achieving stable internal fixation. This article discusses fracture healing in patients with osteoporosis and the principles of fixation. Pharmacotherapy for the patient with osteoporosis is also discussed.

Address: Department of Orthopaedic Surgery, UC Davis, Sacramento, CA 95817, USA.

DOI: 10.1016/j.ocl.2013.01.011

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MeSH Terms: Aged, Atrophy, Bone Substitutes, Fracture Healing, Fractures, Ununited, Humans, Mesenchymal Stem Cells, Periosteum, Signal Transduction, Vitamin D Deficiency