Small-molecule lipid-bilayer anion transporters for biological applications.

Nathalie Busschaert, Philip A Gale

Journal: Angewandte Chemie (International ed. in English) 2013;52(5):1374-82

PMID: 23283851

Abstract

The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.

Address: Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.

DOI: 10.1002/anie.201207535

Link outs

Free resources

Other Literature Sources:

Subscription / membership required

Full Text Sources:

https://doi.org/10.1002/anie.201207535

MeSH Terms: Anions, Antineoplastic Agents, Apoptosis, Cystic Fibrosis, Humans, Ion Transport, Lipid Bilayers, Neoplasms, Prodigiosin