Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action.

Lucie Ježková, Martin Falk, Iva Falková, Marie Davídková, Alena Bačíková, Lenka Štefančíková, Jana Vachelová, Anna Michaelidesová, Emilie Lukášová, Alla Boreyko, Evgeny Krasavin, Stanislav Kozubek

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2014;83 Pt B():128-36

PMID: 23415104

Full Text on Elsevier Science View on PubMed

Abstract

According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.

Address: Institute of Biophysics Brno, Academy of Sciences of the Czech Republic, Brno, Czech Republic; Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia; Institute of Chemical Technology Prague, Prague, Czech Republic.

DOI: 10.1016/j.apradiso.2013.01.022

Link outs

Free resources

Other Literature Sources:

https://scite.ai/reports/23415104

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0969...

MeSH Terms: Cell Nucleus, Cells, Cultured, Chromatin, DNA Damage, DNA Repair, Gamma Rays, Humans, Microscopy, Protons, Translocation, Genetic