Phospholipase A(2) enzymes: structural diversity in lipid messenger metabolism.

A Dessen

Journal: Structure (London, England : 1993) 2000;8(2):R15-22

PMID: 10673441

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Abstract

The phospholipases A(2) (PLA(2)s) are a large family of enzymes with varied lipidic products which are involved in numerous signal transduction pathways. The structural and functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.

Address: European Molecular Biology Laboratory, Grenoble, 38000, France. [email protected].

DOI: 10.1016/s0969-2126(00)00097-6

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MeSH Terms: Calcium, Catalytic Domain, Cytosol, Enzyme Activation, Lipid Metabolism, Membrane Proteins, Phospholipases A, Protein Conformation