Comparative genomic insights into the biosynthesis and regulation of mycobacterial siderophores.

Wu Li, Junli He, Longxiang Xie, Tian Chen, Jianping Xie

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013;31(1):1-13

PMID: 23343601

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Abstract

Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis - Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and regulation differences between the pathogenic and non-pathogenic mycobacteria are highlighted from comparative genomic perspective, with an aim to find clues for drug or drug target within siderophore metabolism.

Address: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing, China.

DOI: 10.1159/000343343

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MeSH Terms: Comparative Genomic Hybridization, Iron, Multigene Family, Mycobacterium, Polyketide Synthases, Siderophores