Bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for control of ocular inflammation and prevention of cystoid macular edema after phacoemulsification.

Qi-wei Wang, Ke Yao, Wen Xu, Pei-qing Chen, Xing-chao Shentu, Xin Xie, Yan Weng, Li Zhang, Chong-fei Jin, Wei Wu, Ya-nan Zhu, Yin-hui Yu

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 2014;229(4):187-94

PMID: 23429038

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Abstract

PURPOSE

To compare bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for the control of postoperative inflammation and prevention of cystoid macular edema (CME) after phacoemulsification.

METHODS

Patients were randomized to receive bromfenac sodium 0.1% for 1 month (OBS1) or 2 months (OBS2), or fluorometholone 0.1% for 1 month (OFM) or dexamethasone 0.1% for 1 month (ODM). Best-corrected visual acuity, intraocular pressure, endothelial cell density, photon count value and retinal foveal thickness were measured.

RESULTS

Mean photon count values were lower in the OBS1 and OBS2 groups compared with the ODM group during the first week. Bromfenac sodium cleared the ocular inflammation more rapidly than fluorometholone and dexamethasone. The foveal thickness was thinner in the second month and the incidence of CME was lower in the OBS1 and OBS2 groups compared with the OFM and ODM groups.

CONCLUSION

Bromfenac sodium was more effective and safer than fluorometholone and dexamethasone as an anti-inflammatory, decreasing macular thickness and preventing CME in age-related cataract patients after cataract surgery.

Address: Eye Center, 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.

DOI: 10.1159/000346847

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MeSH Terms: Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Benzophenones, Bromobenzenes, Dexamethasone, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Fluorescein Angiography, Fluorometholone, Follow-Up Studies, Fundus Oculi, Glucocorticoids, Humans, Macular Edema, Male, Middle Aged, Ophthalmic Solutions, Phacoemulsification, Postoperative Complications, Prospective Studies, Treatment Outcome, Uveitis