Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway.

Qing Ji, Xuan Liu, Xiaoling Fu, Long Zhang, Hua Sui, Lihong Zhou, Jian Sun, Jianfeng Cai, Jianmin Qin, Jianlin Ren, Qi Li

Journal: PloS one 2014;8(11):e78700

PMID: 24244343

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Abstract

Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA and over-expression constructs in CRC derived cell lines, LoVo and HCT116, we demonstrated that the anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/β-catenin signaling, thus the expression of its target genes such as c-Myc, MMP-7, as well as the expression of MALAT1. In detail, resveratrol down-regulates MALAT1, resulting in decreased nuclear localization of β-catenin thus attenuated Wnt/β-catenin signaling, which leads to the inhibition of CRC invasion and metastasis. This finding of ours surely provides important pre-clinical evidence supporting future use of resveratrol in prevention and treatment of CRC.

Address: Department of Medical Oncology, Shuguang Hospital; Shanghai University of Traditional Chinese Medicine, Shanghai, China ; Interventional Cancer Institute & Department of General Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

DOI: 10.1371/journal.pone.0078700

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MeSH Terms: Aged, Antineoplastic Agents, Phytogenic, Cell Line, Tumor, Cell Nucleus, Colorectal Neoplasms, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Matrix Metalloproteinase 7, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Proto-Oncogene Proteins c-myc, RNA, Long Noncoding, RNA, Neoplasm, Resveratrol, Stilbenes, Wnt Signaling Pathway, beta Catenin