Future directions in cancer prevention.

Peter Greenwald, Barbara K Dunn, Asad Umar

Journal: Nature reviews. Cancer 2013;12(12):835-48

PMID: 23151603

Full Text on Nature Publishing Group View on PubMed

Abstract

Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and medical approaches to cancer prevention. These include selective oestrogen receptor modulators and aromatase inhibitors for breast cancer, the 5-α-reductase inhibitors finasteride and dutasteride for prostate cancer, and the development of vaccines for viruses that are associated with specific cancers. Future directions include genetic, proteomic and other molecular approaches for identifying pathways that are associated with cancer initiation and development, as well as refining the search for immunologically modifiable causes of cancer.

Address: National Cancer Institute, Division of Cancer Prevention, Gastrointestinal and Other Cancers Research Group, National Cancer Institute, Executive Plaza North 2142, 6130 Executive Boulevard, MSC 7317, Rockville, Maryland 20852-7371, USA. [email protected]

DOI: 10.1038/nrc3397

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MeSH Terms: Aromatase Inhibitors, Azasteroids, Breast Neoplasms, Cancer Vaccines, Diet, Dutasteride, Female, Finasteride, Humans, Immunotherapy, Life Style, Male, Motor Activity, Neoplasms, Obesity, Prostatic Neoplasms, Selective Estrogen Receptor Modulators, Nicotiana, Vaccines