The efficacy of gabapentin versus stabilization splint in management of sleep bruxism.

Azam Sadat Madani, Ebrahim Abdollahian, Hasan Azangoo Khiavi, Mehrdad Radvar, Mohsen Foroughipour, Hadi Asadpour, Nadia Hasanzadeh

Journal: Journal of prosthodontics : official journal of the American College of Prosthodontists 2014;22(2):126-31

PMID: 22946979

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Abstract

PURPOSE

This study aimed to determine if the use of gabapentin is more efficacious than a stabilization splint with regard to the intensity of masseter muscle contractions and/or sleep quality for patients experiencing sleep bruxism (SB).

MATERIALS AND METHODS

Twenty patients with SB participated in this clinical study. They were randomly divided into two treatment groups: stabilization splint group (n = 10) and gabapentin group (n = 10). The first polysomnographic examination was performed before the beginning of the experiment for all the participants. At the end of a 2-month period of stabilization splint therapy or gabapentin usage, a second polysomnographic recording was made.

RESULTS

Statistically significant reductions in the number of SB episodes per hour and per night, bruxism time index, total duration of SB episodes per night and number of SB episodes in stages NR I and NR II (p < 0.05) were observed in both groups after treatment. Both treatments significantly reduced the mean intensity of masseter muscle contractions during SB episodes. Moreover, the participants treated with gabapentin showed a significant improvement in total sleep time, slow wave sleep (stage III), and sleep efficiency (p < 0.05).

CONCLUSIONS

Gabapentin could be an effective treatment modality in SBs, especially in those with poor sleep quality.

Address: Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.1111/j.1532-849X.2012.00914.x

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MeSH Terms: Adolescent, Adult, Amines, Centric Relation, Cyclohexanecarboxylic Acids, Excitatory Amino Acid Antagonists, Female, Follow-Up Studies, Gabapentin, Humans, Male, Masseter Muscle, Middle Aged, Muscle Contraction, Occlusal Splints, Orthodontic Appliance Design, Polysomnography, Single-Blind Method, Sleep, Sleep Bruxism, Sleep Stages, Treatment Outcome, Young Adult, gamma-Aminobutyric Acid