Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications.

Yan-Ming Sun, Ying Su, Jia Li, Ye Tian, Lan-Feng Wang

Journal: Biochemical and biophysical research communications 2013;427(2):229-31

PMID: 23000155

Full Text on Elsevier Science View on PubMed

Abstract

Micro- and macrovascular complications are the main cause of morbidity and mortality in diabetes mellitus. The Na(+)/H(+) exchanger (NHE) is a family of proteins which exchange Na(+) for H(+) according to their concentration gradients in an electroneutral manner. The exchanger also plays a key role in several other cellular functions including proliferation, differentiation, apoptosis, migration, and cytoskeletal organization. Since not much is known on the relationship between NHE and diabetes mellitus, this review outlines the contribution of NHE to chronic complications of diabetes mellitus, such as diabetic nephropathy; diabetic cardiomyopathy.

Address: Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

DOI: 10.1016/j.bbrc.2012.09.050