Contribution of the OATP1B subfamily to cancer biology and treatment.

W D Figg, T M Sissung, K M Reece, S Spencer

Journal: Clinical pharmacology and therapeutics 2012;92(5):658-60

PMID: 23010650

Free Full Text on PubMed Central View on PubMed

Abstract

The organic anion transporter 1B (OATP1B) subfamily consists of OATP1B1 and OATP1B3. These transporters have generally been considered liver-specific; however, recent evidence demonstrates that they are also expressed in extrahepatic tissues and in some tumors. This review discusses the potential influence of extrahepatic OATP1B expression on homeostasis and pathophysiology and its implications for pharmacotherapy in general.

Address: Clinical Pharmacology Program, National Cancer Institute, Bethesda, Maryland, USA.

DOI: 10.1038/clpt.2012.127

Link outs

Free resources

Full Text Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: Gene Expression Regulation, Gene Expression Regulation, Neoplastic, Humans, Liver, Liver-Specific Organic Anion Transporter 1, Neoplasms, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Solute Carrier Organic Anion Transporter Family Member 1B3