Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis.

F Zhang, Y Yang, D Hu, H Lei, Y Wang

Journal: Genetics and molecular research : GMR 2013;11(3):3511-7

PMID: 23079845

Abstract

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no significant associations between any of these polymorphisms and essential hypertension (allele Arg vs allele Gln: odds ratio (OR) = 0.94, 95% confidence interval (95%CI) = 0.70-1.27), additive genetic model (Arg/Arg vs Gln/Gln: OR = 0.98, 95%CI = 0.43-2.23), dominant genetic model (Arg/Arg + Arg/Gln vs Gln/ Gln: OR = 0.97, 95%CI = 0.43-2.21), and recessive genetic model (Arg/ Arg vs Arg/Gln + Gln/Gln: OR = 1.03, 95%CI = 0.45-2.35). Based on the results of our meta-analysis, we conclude that the TSC gene Arg904Gln polymorphism is not associated with essential hypertension risk.

Address: School of Public Health, Chongqing Medical University, Chongqing, China.

DOI: 10.4238/2012.September.26.7

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MeSH Terms: Alleles, Amino Acid Substitution, Bias, Case-Control Studies, Confidence Intervals, Genes, Dominant, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Hypertension, Models, Genetic, Odds Ratio, Polymorphism, Single Nucleotide, Receptors, Drug, Risk Factors, Sodium Chloride Symporters