Testosterone and muscle protein metabolism.

R Wolfe, A Ferrando, M Sheffield-Moore, R Urban

Journal: Mayo Clinic proceedings 2000;75 Suppl():S55-9; discussion S59-60

PMID: 10959218

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Abstract

This presentation discusses recent investigations into testosterone's effects on muscle protein metabolism. Protein synthesis is the principal end point, but protein breakdown and the availability of an amino acid pool are important to the process of net muscle protein synthesis. The effects of other hormones--including growth hormone, oxoandrolone (a synthetically derived testosterone), and androstenedione--on muscle protein synthesis also are discussed. Effects in both normal and elderly men are considered.

Address: University of Texas Medical Branch, Galveston, USA.

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MeSH Terms: Aged, Aging, Amino Acids, Anabolic Agents, Androstenedione, Growth Hormone, Humans, Male, Middle Aged, Models, Biological, Muscle Proteins, Muscular Atrophy, Oxandrolone, Testosterone, Time Factors