Celiac disease in the developing world.

Kamran Rostami, Carlo Catassi, Kassem Barada, Hussein Abu Daya

Journal: Gastrointestinal endoscopy clinics of North America 2013;22(4):773-96

PMID: 23083993

Full Text on Elsevier Science View on PubMed

Abstract

The prevalence of celiac disease (CD) in many developing countries is similar to that of developed areas, in both low- and high-risk groups. The disorder is underestimated because of lack of disease awareness. CD is strongly associated with HLA-DQ2 in developing countries. Clinical presentation may be characterized by chronic diarrhea, anemia, stunting and increased mortality. Few studies have addressed atypical or silent CD. Diagnosis is initially made by serologic tests and is confirmed by small intestinal biopsies. In developing countries the adherence to the treatment is still difficult because of poor availability of dedicated gluten-free food.

Address: Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Riad-El-Solh Beirut, Lebanon.

DOI: 10.1016/j.giec.2012.07.002

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MeSH Terms: Celiac Disease, Developing Countries, Diet, Gluten-Free, HLA-DQ Antigens, Humans, Prevalence