The successful use of vancomycin-impregnated cement beads in a patient with vancomycin systemic toxicity: a case report with review of literature.

V Mounasamy, P Fulco, P Desai, R Adelaar, G Bearman

Journal: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2014;23 Suppl 2():S299-302

PMID: 23412194

Abstract

We report the use of vancomycin laden antibiotic cement beads in a patient with calcaneal osteomyelitis who had prior acute kidney injury (AKI). The patient experienced non-oliguric renal failure after exposure to intravenous vancomycin and recovered well after antibiotic discontinuation and adequate hydration. We are not aware of any similar case report where vancomycin laden antibiotic cement has been used in a patient with AKI to vancomycin.

Address: Department of Orthopedics, Infectious Diseases, Virginia Common Wealth University Health System, 1200 East Broad Street, 9th floor West Hospital, PO Box 980153, Richmond, VA, 23298-0153, USA, [email protected].

DOI: 10.1007/s00590-012-1062-4

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https://dx.doi.org/10.1007/s00590-012-1062-4

MeSH Terms: Acute Kidney Injury, Administration, Intravenous, Adult, Anti-Bacterial Agents, Bone Cements, Calcaneus, Debridement, Female, Humans, Naphthalenes, Osteomyelitis, Polymers, Vancomycin