Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A.

Jean-Sébastien Joyal, Samy Omri, Nicholas Sitaras, José-Carlos Rivera, Przemyslaw Sapieha, Sylvain Chemtob

Journal: Acta paediatrica (Oslo, Norway : 1992) 2012;101(8):819-26

PMID: 22497252

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Abstract

UNLABELLED

Retinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP. These hypoxia-generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A.

CONCLUSION

Neuron-derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.

Address: Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada.

DOI: 10.1111/j.1651-2227.2012.02692.x

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MeSH Terms: Biomarkers, Humans, Infant, Newborn, Infant, Premature, Receptors, G-Protein-Coupled, Retinal Neovascularization, Retinal Neurons, Retinopathy of Prematurity, Semaphorin-3A