RGG motif proteins: modulators of mRNA functional states.

Purusharth Rajyaguru, Roy Parker

Journal: Cell cycle (Georgetown, Tex.) 2012;11(14):2594-9

PMID: 22767211

Free Full Text on PubMed Central View on PubMed

Abstract

A recent report demonstrates that a subset of RGG-motif proteins can bind translation initiation factor eIF4G and repress mRNA translation. This adds to the growing number of roles RGG-motif proteins play in modulating transcription, splicing, mRNA export and now translation. Herein, we review the nature and breadth of functions of RGG-motif proteins. In addition, the interaction of some RGG-motif proteins and other translation repressors with eIF4G highlights the role of eIF4G as a general modulator of mRNA function and not solely as a translation initiation factor.

Address: Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, The University of Arizona, Tucson, Tucson, AZ, USA.

DOI: 10.4161/cc.20716

Link outs

Free resources

Full Text Sources:

Molecular Biology Databases:

https://www.yeastgenome.org/reference/22767211

Subscription / membership required

Full Text Sources:

https://www.tandfonline.com/doi/10.4161/cc.20716?u...

MeSH Terms: Amino Acid Motifs, Eukaryotic Initiation Factor-4E, Eukaryotic Initiation Factor-4G, Nuclear Proteins, Protein Biosynthesis, Protein-Arginine N-Methyltransferases, RNA, Messenger, RNA-Binding Proteins, Ribonucleoproteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins