Diarrhea caused by circulating agents.

Elisabeth Fabian, Patrizia Kump, Guenter J Krejs

Journal: Gastroenterology clinics of North America 2013;41(3):603-10

PMID: 22917166

Full Text on Elsevier Science View on PubMed

Abstract

Circulating agents cause intestinal secretion or changes in motility with decreased intestinal transit time, resulting in secretory-type diarrhea. Secretory diarrhea as opposed to osmotic diarrhea is characterized by large-volume, watery stools, often more than 1 L per day; by persistence of diarrhea when patients fast; and by the fact that on analysis of stool-water, measured osmolarity is identical to that calculated from the electrolytes present. Although sodium plays the main role in water and electrolyte absorption, chloride is the major ion involved in secretion.

Address: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

DOI: 10.1016/j.gtc.2012.06.008

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MeSH Terms: Calcitonin, Carcinoma, Medullary, Diarrhea, Gastrinoma, Histamine Release, Humans, Hyperthyroidism, Malignant Carcinoid Syndrome, Mast Cells, Mastocytosis, Systemic, Pancreatic Neoplasms, Pancreatic Polypeptide, Somatostatin, Somatostatinoma, Thyroid Neoplasms, Vipoma, Zollinger-Ellison Syndrome