Recognition of distorted DNA structures by HMG domains.

A Travers

Journal: Current opinion in structural biology 2000;10(1):102-9

PMID: 10679469

Full Text on Elsevier Science View on PubMed

Abstract

Recent biochemical and structural studies have shown that the preferential recognition of distorted DNA structures, including DNA bulges, four-way junctions and cis-platinated DNA, by HMG domains is dependent on residues immediately preceding the second alpha helix of the L-shaped HMG domain.

Address: Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK. [email protected]

DOI: 10.1016/s0959-440x(99)00056-1

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MeSH Terms: Amino Acid Sequence, DNA Damage, DNA Repair, High Mobility Group Proteins, Macromolecular Substances, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, Protein Binding, Protein Structure, Tertiary, Sequence Alignment, Sequence Homology, Nucleic Acid, Substrate Specificity