Celiac disease: advances in treatment via gluten modification.

Joseph A Murray, Eric Marietta, Samantha Stoven

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2012;10(8):859-62

PMID: 22728383

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Abstract

Celiac disease (CD) is an autoimmune enteropathy that occurs in genetically susceptible individuals carrying the prerequisite genetic markers HLA DQ2 or DQ8. These genetic markers are present in approximately 30% of the population, and the worldwide prevalence of CD is estimated to be approximately 1%-2%. Currently a gluten-free diet is the only treatment for CD, but novel therapies aimed at gluten modification are underway. This review will discuss gluten-based therapies including wheat alternatives and wheat selection, enzymatic alteration of wheat, oral enzyme supplements, and polymeric binders as exciting new therapies for treatment of CD.

Address: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

DOI: 10.1016/j.cgh.2012.06.005