Mechanistic insight into pentatricopeptide repeat proteins as sequence-specific RNA-binding proteins for organellar RNAs in plants.

Takahiro Nakamura, Yusuke Yagi, Keiko Kobayashi

Journal: Plant & cell physiology 2012;53(7):1171-9

PMID: 22576772

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Abstract

The pentatricopeptide repeat (PPR) protein family is highly expanded in terrestrial plants. Arabidopsis contains 450 PPR genes, which represents 2% of the total protein-coding genes. PPR proteins are eukaryote-specific RNA-binding proteins implicated in multiple aspects of RNA metabolism of organellar genes. Most PPR proteins affect a single or small subset of gene(s), acting in a gene-specific manner. Studies over the last 10 years have revealed the significance of this protein family in coordinated gene expression in different compartments: the nucleus, chloroplast and mitochondrion. Here, we summarize recent studies addressing the mechanistic aspect of PPR proteins.

Address: Department of Research Superstar Program, Institute of Advanced Study, Kyushu University, Fukuoka 812-8581, Japan. [email protected]

DOI: 10.1093/pcp/pcs069

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MeSH Terms: Amino Acid Motifs, Amino Acid Substitution, Arabidopsis, Arabidopsis Proteins, Chloroplasts, Gene Expression Regulation, Plant, Genes, Plant, Mitochondria, RNA, RNA Editing, RNA, Mitochondrial, RNA, Plant, RNA-Binding Proteins, Species Specificity