Blebbing as a physical force in cancer EMT - parallels with mitosis.

Petra Sekyrova, Joel Östblom, Michael Andäng

Journal: Seminars in cancer biology 2013;22(5-6):369-73

PMID: 22659342

Full Text on Elsevier Science View on PubMed

Abstract

Epithelial to mesenchymal transition (EMT) during metastasis is initially a two-step process beginning with delamination of cells from the solid tumor followed by acquisition of a migratory phenotype. Several reports indicate that plasma membrane blebbing, associated with cell division, coincides with cell delamination during developmental EMT. This raises a speculative question if blebbing drives EMT in cancer cells in a similar way. Here, we review available data on factors and processes that may support such a connection.

Address: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 1, SE 171 77 Stockholm, Sweden. [email protected]

DOI: 10.1016/j.semcancer.2012.05.007

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MeSH Terms: Cell Movement, Epithelial-Mesenchymal Transition, Humans, Ions, Mitosis, Neoplasm Metastasis, Neoplasms