Nonsebaceous lymphadenoma of salivary gland: report of a case with immunohistochemistry and review of the literature.

Francesca Angiero, Angelita Ferri, Gabriella Maria Valente, Giorgio Cattoretti

Journal: Oral surgery, oral medicine, oral pathology and oral radiology 2013;114(3):e41-7

PMID: 22862989

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

Nonsebaceous lymphadenomas are rare benign neoplasms. We emphasize the role of immunohistochemistry and attempt to elucidate the pathogenesis by investigating the distribution of 2 transcription factors, MYC and BLIMP1.

STUDY DESIGN

A 70-year-old man was evaluated for a 3-cm left parotid mass. Ultrasound-guided fine-needle aspiration biopsy findings were suggestive of a diagnosis of pleomorphic adenoma. A left superficial parotidectomy was performed, and based on histopathology a diagnosis of lymphadenoma, nonsebaceous type, was rendered.

RESULTS

The tumor was positive for AE1/3, CKA, BclII, P63, CD79a, CD3, and MYC; focally positive for CK7 and epithelial membrane antigen; and negative for CD10, calponin, CD117, and BLIMP1.

CONCLUSIONS

The rarity of nonsebaceous lymphadenoma and its superficial resemblance to commoner salivary gland tumors may present a diagnostic challenge for pathologists. The expression of MYC in the ductal component and the differentiation-related expression of PRDM1 in the superficial keratinizing layers point to a potential role for these 2 transcription factors in the pathogenesis of this neoplasm.

Address: Department of Medical Science, Dentistry, and Biophysics, University of Genoa, Genoa, Italy. [email protected]

DOI: 10.1016/j.oooo.2012.01.021

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MeSH Terms: Adaptor Proteins, Signal Transducing, Adenolymphoma, Adenoma, Pleomorphic, Aged, Cell Differentiation, Diagnosis, Differential, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Follow-Up Studies, Humans, Immunohistochemistry, Keratin-1, Keratin-3, Male, Membrane Proteins, Parotid Neoplasms, Positive Regulatory Domain I-Binding Factor 1, Proto-Oncogene Proteins c-myc, Repressor Proteins, S100 Proteins, Zinc Fingers