Primary sellar neuroblastoma. A new case and review of literature.

Martin Dupuy, Fabrice Bonneville, Solange Grunenwald, Florence Breibach, Marie-Bernadette Delisle, Patrick Chaynes, Jean-Christophe Sol, Philippe Caron

Journal: Annales d'endocrinologie 2012;73(3):216-21

PMID: 22497798

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Abstract

The primary intracranial development of olfactory neuroblastomas, outside olfactory epithelium, is rare. We report a case of primary sellar neuroblastoma without any aggressive histopathological features, managed solely surgically without adjuvant therapy, with good outcomes at 3 years. Primary sellar neuroblastomas mostly occur in women in the 4th decade with a context of a non-secreting pituitary tumour. Diagnosis is made on histopathological examination (small cells, fibrillary intercellular background, strong immunoreactivity for neurons markers, negative immunoreactivity for anterior pituitary hormones). Management is based on surgery. Adjuvant treatment is not consensual, largely depends on patient's conditions and aggressive histopathological features.

Address: Service de neurochirurgie, centre hospitalo-universitaire Rangueil, 1, avenue du Pr-Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France. [email protected]

DOI: 10.1016/j.ando.2012.02.001

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MeSH Terms: 3-Iodobenzylguanidine, Adenoma, Adult, Amenorrhea, Biomarkers, Tumor, Diagnosis, Differential, Esthesioneuroblastoma, Olfactory, Female, Humans, Hyperprolactinemia, Hypophysectomy, Inappropriate ADH Syndrome, Iodine Radioisotopes, Magnetic Resonance Imaging, Neoplasm Proteins, Pituitary Neoplasms, Prognosis, Radiopharmaceuticals, Remission Induction, Sella Turcica, Supratentorial Neoplasms, Vision Disorders, Whole Body Imaging