Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: a systematic review.

Louise H Dekker, Karin Fijnvandraat, Bernard J Brabin, Michael Boele van Hensbroek

Journal: Pediatric blood & cancer 2012;59(2):211-5

PMID: 22492631

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Abstract

Patients with Sickle cell disease (SCD) exhibit signs of poor growth, increased susceptibility to infection and recurrent episodes of painful vaso-occlusive crises. Micronutrient deficiencies may increase susceptibility to these outcomes. We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized-controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega-3 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions.

Address: Department of Public Health, Academic Medical Center, Amsterdam, The Netherlands. [email protected]

DOI: 10.1002/pbc.24163

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https://medlineplus.gov/sicklecelldisease.html

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https://assays.cancer.gov/CPTAC-1496

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MeSH Terms: Anemia, Sickle Cell, Arterial Occlusive Diseases, Humans, Infections, Micronutrients