Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.

Alina Minarowska, Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko

Journal: Folia histochemica et cytobiologica 2012;50(1):20-4

PMID: 22532132

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).

Address: Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland.

DOI: 10.2478/18692

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MeSH Terms: Amino Acid Sequence, Cathepsin A, Cathepsin C, Glycoside Hydrolases, Humans, Models, Molecular, Molecular Sequence Data