Iron metabolism: interactions with normal and disordered erythropoiesis.

Elizabeta Nemeth, Tomas Ganz

Journal: Cold Spring Harbor perspectives in medicine 2013;2(5):a011668

PMID: 22553501

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Abstract

Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.

Address: Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. [email protected]

DOI: 10.1101/cshperspect.a011668

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MeSH Terms: Anemia, Biological Transport, Chronic Disease, Erythroid Cells, Erythropoiesis, Hemoglobinopathies, Homeostasis, Humans, Iron, Iron Deficiencies, Iron Metabolism Disorders, Mitochondria, Protein Biosynthesis