Structure and biosynthesis of human salivary mucins.

A Zalewska, K Zwierz, K Zółkowski, A Gindzieński

Journal: Acta biochimica Polonica 2002;47(4):1067-79

PMID: 11996097

Abstract

Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.

Address: Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland. [email protected]

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MeSH Terms: Amino Acid Sequence, Carbohydrate Sequence, Glycosylation, Humans, Molecular Sequence Data, Mucin-5B, Mucins, Oligosaccharides, Peptides, Protein Structure, Tertiary, Saliva, Salivary Proteins and Peptides, Sequence Homology, Amino Acid