Advanced search

MicroRNAs in metabolism and metabolic disorders.

Veerle Rottiers, Anders M Näär

Journal: Nature reviews. Molecular cell biology 2012;13(4):239-50

PMID: 22436747

Free Full Text on PubMed Central View on PubMed

Abstract

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.

Address: Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
DOI: 10.1038/nrm3313

Link outs

Free resources

Full Text Sources:

Medical:

Other Literature Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: Cholesterol, Endocrine System, Fatty Liver, Glucose, Homeostasis, Humans, Insulin, Lipid Metabolism, Metabolic Diseases, Metabolic Syndrome, MicroRNAs, Non-alcoholic Fatty Liver Disease, Obesity, Oligoribonucleotides, Antisense, Signal Transduction, Sterol Regulatory Element Binding Proteins
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

Sponsor Sponsor Sponsor Sponsor Sponsor Sponsor Sponsor

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.