Structure, function and regulation of spliceosomal RNA helicases.

Olivier Cordin, Daniela Hahn, Jean D Beggs

Journal: Current opinion in cell biology 2013;24(3):431-8

PMID: 22464735

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Abstract

Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.

Address: Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

DOI: 10.1016/j.ceb.2012.03.004

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MeSH Terms: Adenosine Triphosphatases, Amino Acid Sequence, DEAD-box RNA Helicases, Gene Expression Regulation, Humans, RNA Helicases, RNA Precursors, RNA Splicing, Spliceosomes