MEN1 and pituitary adenomas.

Brigitte Delemer

Journal: Annales d'endocrinologie 2012;73(2):59-61

PMID: 22542456

Full Text on Elsevier Science View on PubMed

Abstract

MEN1 gene mutations predispose carriers to pituitary tumors. Molecular pathways involved in the development of these tumors seem different to what is known in sporadic tumors. Clinical studies showed that all types of adenomas can be found with a predominance of prolactinoma and macroadenoma compared to a control population. These MEN1 tumors seem more aggressive, invasive and resistant to treatment requiring a very careful long-life follow-up. Occurrence of these tumors can be described in the pediatric population and it can be the first and only manifestation of MEN1 for some years asking the question of the systematic screening for MEN1 gene mutation in pediatric population with pituitary adenoma.

Address: Service d'endocrinologie-diabète-nutrition, CHU de Reims, France. [email protected]

DOI: 10.1016/j.ando.2012.03.038

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MeSH Terms: Adenoma, Child, Humans, Multiple Endocrine Neoplasia Type 1, Mutation, Pituitary Neoplasms, Proto-Oncogene Proteins