Ovarian cancer: etiology, risk factors, and epidemiology.

Jessica Hunn, Gustavo C Rodriguez

Journal: Clinical obstetrics and gynecology 2012;55(1):3-23

PMID: 22343225

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Little is known regarding the early aspects of ovarian carcinogenesis. As a consequence, the identification of women at risk for the disease is based primarily on clinical grounds, with family history being the most important risk factor. In this review, we will discuss the various hypotheses regarding ovarian etiology and pathogenesis. In addition, we will discuss the epidemiology of ovarian cancer, including hereditary, reproductive, hormonal, inflammatory, dietary, surgical, and geographic factors that influence ovarian cancer risk.

Address: Division of Gynecologic Oncology, NorthShore University Healthsystem, Department of Obstetrics and Gynecology, University of Chicago, Evanston, Illinois 60201, USA.

DOI: 10.1097/GRF.0b013e31824b4611

Link outs

Free resources

Medical:

https://medlineplus.gov/ovariancancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Androgens, Breast Feeding, Contraceptives, Oral, Hormonal, Diet, Endometriosis, Epithelium, Estrogens, Exercise, Female, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Geography, Gonadotropins, Hormone Replacement Therapy, Humans, Hysterectomy, Inflammation, Life Style, Lynch Syndrome II, Mutation, Obesity, Ovarian Neoplasms, Parity, Pelvic Inflammatory Disease, Pregnancy, Progestins, Risk Factors, Smoking, Sterilization, Tubal, Talc