Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.

Carsten Skarke, Karina Kuczka, Lars Tausch, Oliver Werz, Tanja Rossmanith, Jeffrey S Barrett, Sebastian Harder, Wolfgang Holtmeier, Joachim A Schwarz

Journal: Journal of clinical pharmacology 2013;52(10):1592-600

PMID: 22167571

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Abstract

Address: Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. [email protected]

DOI: 10.1177/0091270011422811

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MeSH Terms: Administration, Oral, Biological Availability, Boswellia, Cathepsin G, Computer Simulation, Cross-Over Studies, Eicosanoids, Fasting, Food-Drug Interactions, Humans, Male, Meals, Models, Biological, Plant Extracts, Platelet Aggregation, Triterpenes