Eosinophilic esophagitis: diagnosis and management.

Jay A Lieberman, Mirna Chehade

Journal: Immunology and allergy clinics of North America 2012;32(1):67-81

PMID: 22244233

Full Text on Elsevier Science View on PubMed

Abstract

Eosinophilic esophagitis is a clinicopathologic disease that can present with a constellation of upper gastrointestinal symptoms and endoscopic findings in conjunction with significant infiltration of the esophageal tissue with eosinophils. Clinical and histologic resolution of the disease can be seen with dietary restriction therapies and systemic and topical corticosteroids. Because most patients have an atopic background and the disease seems to have an underlying T-helper type 2 pathogenesis, allergists and gastroenterologists need to be familiar with the diagnosis and management of this disease. In this review, clinical characteristics, endoscopic and histologic findings, and available therapy options are discussed.

Address: Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

DOI: 10.1016/j.iac.2011.11.006

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MeSH Terms: Age Factors, Androstadienes, Budesonide, Eosinophilic Esophagitis, Eosinophils, Esophagus, Fluticasone, Food, Food Hypersensitivity, Humans, Sex Factors