Is seladin-1 really a selective Alzheimer's disease indicator?

Laura J Sharpe, Jenny Wong, Brett Garner, Glenda M Halliday, Andrew J Brown

Journal: Journal of Alzheimer's disease : JAD 2012;30(1):35-9

PMID: 22387408

Abstract

Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name "Seladin-1" and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.

Address: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

DOI: 10.3233/JAD-2012-111955

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MeSH Terms: Alzheimer Disease, Brain, Down-Regulation, Humans, Nerve Tissue Proteins, Neurofibrillary Tangles, Oxidoreductases Acting on CH-CH Group Donors