Preeclampsia, placenta, oxidative stress, and PMCA.

Cilia Abad, Teresa Proverbio, Sandy Piñero, Desirée Botana, Delia I Chiarello, Reinaldo Marín, Fulgencio Proverbio

Journal: Hypertension in pregnancy 2013;31(4):427-41

PMID: 22676487

Abstract

OBJECTIVE

The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration.

METHODS

Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included.

RESULTS

Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described.

CONCLUSIONS

Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.

Address: Laboratorio de Bioenergética Celular, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

DOI: 10.3109/10641955.2012.690058

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MeSH Terms: Female, Humans, Lipid Peroxidation, Oxidative Stress, Placenta, Plasma Membrane Calcium-Transporting ATPases, Pre-Eclampsia, Pregnancy