Recent lipase-catalyzed hydrolytic approaches to pharmacologically important β- and γ-amino acids.

E Forró, F Fülöp

Journal: Current medicinal chemistry 2013;19(36):6178-87

PMID: 23061625

Abstract

Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and γ-amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO(2) medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.

Address: Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary. [email protected]

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MeSH Terms: Amino Acids, Biocatalysis, Burkholderia cepacia, Candida, Hydrolysis, Kinetics, Lactams, Lipase, Solvents, Stereoisomerism