Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - relationship to auditory event-related potentials.

James M Stone, Elvira Bramon, Astrid Pauls, Alex Sumich, Philip K McGuire

Journal: Psychiatry research 2010;183(2):174-6

PMID: 20620033

Full Text on Elsevier Science View on PubMed

Abstract

Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments.

Address: Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK. [email protected]

DOI: 10.1016/j.pscychresns.2010.05.004

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MeSH Terms: Acoustic Stimulation, Adult, Aspartic Acid, Electroencephalography, Evoked Potentials, Auditory, Female, Frontal Lobe, Glutamic Acid, Glutamine, Humans, Linear Models, Magnetic Resonance Spectroscopy, Male, Neurochemistry, Protons, Radionuclide Imaging, Schizophrenia, Thalamus, Young Adult