Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring.

Yakup Tomak, Murat Tekin, Ismail Kati, Ceyda Belenli, Meltem Aydogmus

Journal: Magnesium research 2012;24(4):181-8

PMID: 22064369

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Abstract

BACKGROUND

In this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO(4)) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring.

PATIENTS AND METHODS

Sixty patients undergoing abdominal surgery under general anesthesia were randomized into two groups: Mg - receiving perioperative MgSO(4) supplementation and C - control. Anesthesia was titrated to maintain the BIS value between 45-55.

RESULTS

MAC values, tachycardia and hypertension during intubation was found to be lower in group Mg compared to group C (p<0.001). Time to extubation, verbal cooperation and eye opening was longer in patients receiving infusion of MgSO(4) (p<0.001).

CONCLUSION

We concluded that perioperative MgSO(4) infusion may be used as an adjunct as it decreases MAC of desflurane and suppresses the hemodynamic response to intubation.

Address: Department of Anesthesiology, Faculty of Medicine, Rize University, Rize, Turkey. [email protected]

DOI: 10.1684/mrh.2011.0294

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MeSH Terms: Adolescent, Adult, Anesthetics, Inhalation, Consciousness Monitors, Desflurane, Female, Humans, Isoflurane, Magnesium Sulfate, Male, Middle Aged, Monitoring, Intraoperative, Osmolar Concentration, Perioperative Period, Pulmonary Alveoli, Time Factors, Young Adult