Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors.

Wanyan Deng, Honghai Wang, Jianping Xie

Journal: Journal of cellular biochemistry 2012;112(10):2655-62

PMID: 21608015

Abstract

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C products) family transcriptional regulators, widespread among bacteria and archaea, is also known as feast/famine regulatory protein (FFRPs). They regulate multiple cellular metabolisms globally (Lrp) or specifically (AsnC), such as amino acid metabolism, pili synthesis, DNA transactions during DNA repair and recombination, and also might be implicated in persistence. To better understanding of the pathogenesis of M. tuberculosis, based on our lab's work on this transcriptional factor family, these progresses are summarized, with special focus on that of Mycobacterium via comparative genomics.

Address: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three GorgesArea, School of Life Sciences, Southwest University, Chongqing 400715, China.

DOI: 10.1002/jcb.23193

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https://doi.org/10.1002/jcb.23193

MeSH Terms: Amino Acid Sequence, Bacterial Proteins, Gene Expression Regulation, Bacterial, Leucine-Responsive Regulatory Protein, Molecular Sequence Data, Mycobacterium tuberculosis, Sequence Homology, Amino Acid