Acute promyelocytic leukemia with complex translocation t(5;17;15)(q35;q21;q22): case report and review of the literature.

Sung Ran Cho, Seo-Jin Park, Hyon J Kim, Il Joong Park, Jong Rak Choi, Hyun Joo Jung, Jun Eun Park

Journal: Journal of pediatric hematology/oncology 2012;33(7):e326-9

PMID: 21617563

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Abstract

The t(15;17)(q22;q21), resulting in PML-RARA fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). We report a pediatric APL case with a 3-way translocation: t(5;17;15)(q35;q21;q22). Complete blood cell counts of a 12-year-old girl, of pale appearance, showed pancytopenia with increased blasts. Morphology and immunophenotype of the leukemic cells were compatible with APL. Karyotype analysis showed t(5;17;15)(q35;q21;q22) and add(7)(q32). We detected the PML-RARA fusion gene by both reverse transcriptase-polymerase chain reaction and fluorescent in situ hybridization analysis. The patient underwent successful treatment with cytarabine with all-trans retinoic acid and anthracycline-based therapy.

Address: Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.

DOI: 10.1097/MPH.0b013e31820998de

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MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Child, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 5, Female, Humans, In Situ Hybridization, Fluorescence, Leukemia, Promyelocytic, Acute, Reverse Transcriptase Polymerase Chain Reaction