Cardiovascular pharmacogenomics.

Dan M Roden, Julie A Johnson, Stephen E Kimmel, Ronald M Krauss, Marisa Wong Medina, Alan Shuldiner, Russell A Wilke

Journal: Circulation research 2011;109(7):807-20

PMID: 21921273

Abstract

Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.

Address: Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA. [email protected]

DOI: 10.1161/CIRCRESAHA.110.230995

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MeSH Terms: Biological Transport, Biotransformation, Cardiovascular Agents, Cardiovascular Diseases, Drug Dosage Calculations, Genetic Variation, Humans, Patient Selection, Pharmacogenetics, Precision Medicine, Risk Assessment, Treatment Outcome