Combined experimental and computational strategies define an expansive regulon for GcvB small RNA.

Carin K Vanderpool

Journal: Molecular microbiology 2012;81(5):1129-32

PMID: 21815948

Abstract

The bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid transporters and has been postulated to limit uptake of unnecessary amino acids under nutrient-rich conditions. In this issue of Molecular Microbiology, Sharma et al. (2011) provide evidence for a much broader role for GcvB as a global regulator of amino acid metabolism. Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date.

Address: Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. [email protected]

DOI: 10.1111/j.1365-2958.2011.07780.x

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MeSH Terms: Amino Acid Transport Systems, Amino Acids, Bacterial Proteins, Biological Transport, Active, DNA-Binding Proteins, Gene Expression Regulation, Bacterial, Glycine, Protein Biosynthesis, RNA, Bacterial, RNA, Messenger, RNA, Small Cytoplasmic, RNA, Small Untranslated, Regulon, Transcription Factors