TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.

Delphine Javelaud, Vasileia I Alexaki, Sylviane Dennler, Khalid S Mohammad, Theresa A Guise, Alain Mauviel

Journal: Cancer research 2011;71(17):5606-10

PMID: 21862631

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Abstract

The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

Address: Institut Curie, Centre de Recherche, France.

DOI: 10.1158/0008-5472.CAN-11-1194

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MeSH Terms: Bone Neoplasms, Breast Neoplasms, Disease Progression, Female, Hedgehog Proteins, Humans, Kruppel-Like Transcription Factors, Melanoma, Neoplasm Metastasis, Neoplasms, Nuclear Proteins, Signal Transduction, Skin Neoplasms, Smad Proteins, Transforming Growth Factor beta, Zinc Finger Protein Gli2